Trifluoroacetic acid → HCID 59536633, compound

Participants

Reaction Steps

Add trifluoroacetic acid (1.51 g, 1.0 mL, 13.2 mmol) to a solution of (3S)-3-[1-(6-chloro-2-methyl-3-pyridyloxy)-2-cyclopropyl-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (S-1) (99.0 mg, 0.260 mmol) in methoxybenzene (1.0 mL) and dichloromethane (2.0 mL). Stir under nitrogen at room temperature for 1 h. Load the mixture directly onto a pre-packed SCX column and rinse with CH2Cl2 followed by CH3OH. Elute with 2M NH3 in methanol and concentrate under reduced pressure to give 58 mg (79%) of (3S)-3-[1-(6-chloro-2-methyl-3-pyridyloxy)-2-cyclopropyl-ethyl]-pyrrolidine (S-1). MS (m/z)=281.2 [M+1]

Provenance & Evidence