Trifluoroacetic acid → HCID 59536633, compound

Participants

Reaction Steps

Mix (3S)-3-[1-(6-chloro-2-methyl-3-pyridyloxy)-2-cyclopropyl-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (S-1) (0.50 g, 1.31 mmol), methoxybenzene (6.6 mL) and dichloromethane (6.6 mL) in a reaction vial. Evacuate the vial and purge with nitrogen. Add trifluoroacetic acid (1.51 g, 1.0 mL, 13.2 mmol) and stir the mixture at room temperature for 1 h. Load the mixture directly onto a pre-packed SCX column and rinse with CH2Cl2 followed by CH3OH. Elute with 2M NH3 in methanol and concentrate under reduced pressure to give 0.353 g (96%) of (3S)-3-[1-(6-chloro-2-methyl-3-pyridyloxy)-2-cyclopropyl-ethyl]-pyrrolidine (S-1). MS (m/z)=281.2 [M+1].

Provenance & Evidence