HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-cyanocyclohexane-1-carboxylate → Ethyl 1-(aminomethyl)cyclohexane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-cyanocyclohexane-1-carboxylate | HCID 10997650 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 1-(aminomethyl)cyclohexane-1-carboxylate | HCID 21840381 | 80% |
Reaction Steps
Excess Raney Nickel in an ethanol slurry was added to a solution of 1-cyano-cyclohexanecarboxylic acid ethyl ester in ethanol under a nitrogen atmosphere. The nitrogen atmosphere was replaced with excess hydrogen gas and the mixture was allowed to stir overnight. The reaction mixture was filtered through celite and the solvent was removed. The compound was clean enough to continue without purification. 80% yield. MH+=186.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173689B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d021f23b5c264095b84c940ff9912522 |
| Source note | uspto-grants-2012_05 |