HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1922221Erstellt: 25. Oktober 2026
Cyclohexanemethylamine → 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide
https://huagongshe.com/reaction/1922221
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
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| Edukt | Cyclohexanemethylamine | HCID 76688 | — |
| Edukt | 2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]- | HCID 57725393 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide | HCID 57725483 | — |
Reaktionsschritte
To the solution of 4-(2-methanesulfinyl-benzothiazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (25 mg, 0.072 mmol, 1.0 eq) in DMF (500 μL), was added cyclohexylmethylamine (18.7 μL, 0.144 mmol, 2.0 eq) and reaction was stirred at 70° C. overnight. The neat reaction mixture was purified on reverse phase preparatory HPLC. Pure fractions were lyophilized as TFA salts. M+H=397.1
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08173689B2 |
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| Quelldatensatz | uspto-grants-2012_05 |
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| ORD ID | ord-905c8fbe415a4e8ebaca37635996971e |
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| Quellennotiz | uspto-grants-2012_05 |
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