HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1922224Generated: November 4, 2026
1,2-Diaminocyclohexane, trans- → HCID 57725653, compound
https://huagongshe.com/reaction/1922224
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Diaminocyclohexane, trans- | HCID 43806 | — |
| Reactant | 2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]- | HCID 57725393 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 57725653 | HCID 57725653 | 69.8% |
Reaction Steps
To the solution of N-methyl-4-(2-(methylsulfinyl)benzo[d]thiazol-6-yloxy)picolinamide (15 mg, 43 μmole) in 400 μL of NMP was added (1R,2R)-cyclohexane-1,2-diamine (17 mg, 150 μmole). The reaction solution was stirred at 105° C. for 24 hours. The crude reaction solution was purified on prep HPLC and evaporated in vacuo to give 4-(2-((1R,2R)-2-aminocyclohexylamino)benzo[d]thiazol-6-yloxy)-N-methylpicolinamide (12 mg, 30 μmole) as white powder. ES/MS m/z 398.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08173689B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-6167d932744944829e018c32664edf73 |
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| Source note | uspto-grants-2012_05 |
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