反应详情

温度

0 °C

To a stirring solution of 1-(6-methyl-3-pyridinyl)ethanone (1.0 g, 7.4 mmol) in absolute ethanol (10 ml) at 0° C. was added sodium borohydride (0.14 g, 3.7 mmol) portionwise over 20 minutes. The reaction mixture was stirred at 0° C. for 1.5 hours before warming to room temperature. The mixture was partitioned between dichloromethane and saturated aqueous sodium hydrogen carbonate. The organic phase was dried over sodium sulphate, filtered, and evaporated in vacuo to give the crude product 1-(6-methyl-3-pyridinyl)ethanol (810 mg).

1. temperaturebefore warming to room temperature
2. customThe mixture was partitioned between dichloromethane and saturated aqueous sodium hydrogen carbonate
3. dry with materialThe organic phase was dried over sodium sulphate
4. filtrationfiltered
5. customevaporated in vacuo