Hydrochloric Acid → N-{(2S)-5-[(2-methyl-3-pyridinyl)oxy]-2,3-dihydro-1H-inden-2-yl}-2-propanesulfonamide, hydrochloride

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Reaction Steps

N-{(2S)-5-[(2-methyl-3-pyridinyl)oxy]-2,3-dihydro-1H-inden-2-yl}-2-propanesulfonamide (free base, 7.08 g, 20.44 mmol) was dissolved in methanol (150 mL) and dichloromethane (75 mL). HCl (1M in ether, 21.46 mL, 21.46 mmol) was added dropwise at 0° C. and the mixture was stirred at room temperature for 20 minutes. Solvent was removed under reduced pressure to obtain the title compound (7.9 g) containing a minor amount of methanol. 1 g of this material was dried under reduced pressure at 60° C. for 60 hours to give 0.98 g of the title compound.

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