Dichloromethane → HCID 131729714, compound

Participants

Reaction Steps

A mixture of N-[(2S)-5-hydroxy-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide (200 mg, 0.783 mmol, Description 3) and (2-methyl-4-pyridinyl)methanol (107 mg, 0.783 mmol) in dichloromethane (15 ml) was stirred under argon at room temperature, Triphenylphosphine (205 mg, 0.783 mmol) and diisopropyl azodicarboxylate (0.152 ml, 0.783 mmol) were then successively added. The resulting mixture was stirred at room temperature under argon for 16 hours. Solvent was removed by rotary evaporation and the desired product was purified by SCX eluting with 1M ammonia in methanol solution and high pH MDAP to give the title compound as a white solid. The free base solid was dissolved in methanol and treated with ethereal hydrochloride to give the desired compound as a hydrochloride salt (54 mg).

Provenance & Evidence