Hydrochloric Acid → HCID 178478751, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl-3-(6-(thiophene-2-carboximidamido)-3,4-dihydroquinolin-1(2H)-yl)pyrrolidine-1-carboxylate (150 mg, 0.35 mmol) in 5 mL methanol was treated with 10 mL 1N HCl then heated at 70° C. for 30 minutes. The solution was concentrated and dried under reduced pressure to give a yellow solid. This solid was triturated with 5% MeOH/95% Et2O. The yellow solid was collected and dried under reduced pressure. Yield: 125 mg (89.3%). 1H-NMR (DMSO-d6) δ 11.23 (s, 1H), 9.78 (brs, 1H), 9.65 (brs, 1H, 9.59 (brs, 1H), 8.61 (s, 1H), 8.15-8.14 (m, 2H), 7.36 (pseudo t, J=4.5 Hz, 1H), 7.09-6.88 (m, 3H), 4.76-4.66 (m, 1H), 3.39-3.06 (m, 6H), 2.72 (t, J=5.4 Hz, 2H), 2.16-2.01 (m, 2H), 1.87-1.83 (m, 2H). MS (EI): 327.2 (M+1). ESI-HRMS calculated for C18H23N4S (MH+): 327.1637, Observed: 327.1649.

Provenance & Evidence