HCID 59807093, compound → HCID 59807105, compound

Participants

Reaction Steps

A solution of compound 2 (500 mg, 1.56 mmol) in dry ethanol (10 mL) was treated with Pd—C (˜0.05 g) and purged with hydrogen gas. The reaction mixture was stirred at room temperature under hydrogen atmosphere (balloon pressure) overnight (18 h). The mixture was filtered through a celite bed and washed with methanol (3×25 mL). The combined organic fractions were dried under reduced pressure to obtain crude compound 3 (0.5 g, quantitative) as a colourless foam. 1H-NMR (DMSO-d6) δ 1.34 (m, 6H), 1.87-2.22 (m, 10H), 5.00-5.03 (m, 2H), 6.34-6.52 (m, 2H), 6.98 (d, 1H, J=8.4 Hz); ESI-MS (m/z, %): 288.2 (MH+, 100), 203.1 (37).

Provenance & Evidence