Hydrochloric Acid → HCID 178511882, compound

Participants

Reaction Steps

A solution of compound 6 (0.35 g, 0.848 mmol) in methanol (10 mL) was treated with 1 N HCl (10 mL) and the resulting mixture was refluxed for 30 minutes. The reaction was brought to room temperature and solvent was evaporated. The crude product was dissolved into water (10 mL), filtered and washed. Water was evaporated to obtain compound 49 (0.3 g, 92%) as a solid. 1H NMR (DMSO-d6) δ11.25 (s, 1H), 9.82-9.60 (m, 3H), 8.63 (s, 1H), 8.15-8.13 (m, 2H), 7.36 (t, 1H, J=4.5 Hz), 7.12-7.06 (m, 2H), 6.68 (d, 1H, J=8.4 Hz), 4.39-4.35 (m, 1H), 3.56-3.06 (m, 6H), 2.96 (t, 2H, J=8.1 Hz), 2.18-2.00 (m, 2H); ESI-MS (m/z, %): 313 (MH+, free base, 100), 244 (61); ESI-HRMS calculated for C17H21N4S (MH+, free base), calculated: 313.1481; observed: 313.1473; HPLC-purity: 94.05% by area.

Provenance & Evidence