Hydrochloric Acid → HCID 178478751, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 3-(6-(thiophene-2-carboximidamido)-3,4-dihydroquinolin-1(2H)-yl)pyrrolidine-1-carboxylate (Isomer 1) (520 mg, 1.219 mmol) in MeOH (26 ml) was treated with 3N HCl (4.06 ml, 12.19 mmol) then heated at 90° C. for 30 minutes. After cooling, the mixture was concentrated to dryness and dried under reduced pressure overnight. The solid was triturated with 5% isopropanol/95% hexanes (50 mL), collected and dried under reduced pressure (450 mg, 92%). ESI-MS (m/z, %) 327.2 (MH+, 65%), 258.1 (100%); ESI-HRMS calculated for C18H23N4S (MH+), Calculated: 327.1637; Observed: 326.1650; Chemical purity: 97.7%; Optical Rotation: 25[α]589=−0.19°, c=1.05 in MeOH.

Provenance & Evidence