Hydrochloric Acid → HCID 178478751, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 3-(6-(thiophene-2-carboximidamido)-3,4-dihydroquinolin-1(2H)-yl)pyrrolidine-1-carboxylate (Isomer 2) (520 mg, 1.219 mmol) in MeOH (26 ml) was treated with 3N HCl (4.06 ml, 12.19 mmol) then heated at 90° C. for 30 minutes. After cooling, the mixture was concentrated to dryness and dried under reduced pressure overnight. The solid was triturated with 5% isopropanol/95% hexanes (50 mL), collected and dried under reduced pressure (391 mg, 80%). ESI-MS (m/z, %) 327.2 (MH+, 90%), 258.1 (100%); ESI-HRMS calculated for C18H23N4S (MH+), Calculated: 327.1637; Observed: 326.1635; Chemical purity: 97.3%; Optical Rotation: 25[α]589=+0.19°, c=0.95 in methanol.

Provenance & Evidence