HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-(3-iodophenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Iodoaniline | HCID 12271 | — |
| Reactant | Phenyl (7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate | HCID 59731048 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-(3-iodophenyl)urea | HCID 59731045 | 47% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Next, a mixture of phenyl (7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate (30.0 mg, 0.11 mmol) and 3-iodoaniline (25.5 mg, 0.12 mmol) in 0.2 mL of DMSO was heated at 100° C. for 16 hours. After cooled to room temperature, water was added and the product was extracted with ethylacetate. The organic layer was washed with water then brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to obtain N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N′-(3-iodophenyl)urea (20.3 mg, 47% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173841B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ec4a67f697024db68522e138e4805574 |
| Source note | uspto-grants-2012_05 |