HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1922552Generated: October 31, 2026
Water → 2,2-Dimethyl-5,5-bis(4-nitrobenzyl)-1,3-dioxane-4,6-dione
https://huagongshe.com/reaction/1922552
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Reactant | 4-Nitrobenzyl bromide | HCID 66011 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2,2-Dimethyl-5,5-bis(4-nitrobenzyl)-1,3-dioxane-4,6-dione | HCID 4619458 | — |
Reaction Steps
15.0 g (69.4 mmol) of 4-nitrobenzylbromide and 5.00 g (34.7 mmol) of Meldrum's acid are dissolved in 100 ml 2-butanone. 4.40 g (104.1 mmol) potassium carbonate are added, the resulting suspension is heated to 50° C. and allowed to react for 2.5 hours. After cooling to room temperature, 100 ml water are added. The product is collected by filtration and washed with a lot of water. 12.3 g (85%) of 2,2-dimethyl-5,5-bis(4-nitrobenzyl)-1,3-dioxane-4,6-dione as yellowish powder is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08173749B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-a24a193e2c7d45ba8ede2dc204f43c61 |
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| Source note | uspto-grants-2012_05 |
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