HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Piperidyl)-2-propanol → 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Piperidyl)-2-propanol | HCID 5200321 | — |
| Reactant | 4-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine | HCID 59603481 | — |
| Product | 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol | HCID 59603426 | 93.2% |
Reaction Steps
2-(Piperidin-4-yl)propan-2-ol (0.73 g) was reacted with 4-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine (1.6 g) via General Procedure C to yield 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol (1.76 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173650B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-13508dafb90a4c4aa676f86628cadf5e |
| Source note | uspto-grants-2012_05 |