HRID1922894

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID311870

4-bromoisoquinolin-1-amine

C9H7BrN2

结构：CC(C)(O)C1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1

HCID57494032

1-[[2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-α,α-dimethyl-4-piperidinemethanol

C19H27ClN4O2S

PRODUCTS

生成物

结构：CC(C)(O)C1CCN(Cc2cc3nc(-c4cnc(N)c5ccccc45)nc(N4CCOCC4)c3s2)CC1

HCID59606185

未命名化合物

PROCEDURE

实验过程

Following the procedures for 108, 2-(1-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol and 4-bromoisoquinolin-1-amine were converted to 130. LCMS: M+H+=519. 1H NMR (400 MHz, DMSO) δ 8.99 (d, J=8.5, 1H), 8.58 (s, 1H), 8.26 (d, J=8.5, 1H), 8.17 (s, 2H), 7.68 (t, J=7.6, 1H), 7.50 (t, J=7.5, 1H), 7.37 (s, 1H), 7.12 (s, 1H), 4.00-3.89 (m, 4H), 3.86-3.75 (m, 6H), 2.99 (d, J=11.0, 2H), 1.97 (t, J=11.2, 2H), 1.65 (t, J=15.4, 2H), 1.37-1.11 (m, 3H), 1.04 (s, 6H)