反应详情

温度

50 °C

To a suspension of 4-bromo-1 chloroisoquinoline (0.831 g, 3.43 mmol) in MeOH (10.3 mL, 254 mmol) was added ethylamine (70% in water, 1.1 mL). The mixture was heated at 50° C. for 16 h. The mixture was concentrated. The residue was partitioned between water (20 mL) and DCM (20 mL). DCM layer was separated. The aqueous layer was extracted with DCM (10 mL) The combined DCM solutions were dried (Na2SO4). Filtration and concentration gave 4-bromo-N-ethylisoquinolin-1-amine (0.761 g, 88%). LCMS: M+H+=251.

1. concentrationThe mixture was concentrated
2. customThe residue was partitioned between water (20 mL) and DCM (20 mL)
3. customDCM layer was separated
4. extractionThe aqueous layer was extracted with DCM (10 mL) The combined DCM solutions
5. dry with materialwere dried (Na2SO4)
6. filtrationFiltration and concentration