5-Azaindole → HCID 59606133, compound

HRID 1922909Notes

Reaction equation

HRID 1922909 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([N:18]([CH3:20])[CH3:19])[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[NH:27]1[C:35]2[CH:34]=[CH:33][N:32]=[CH:31][C:30]=2[CH:29]=[CH:28]1>>[CH3:19][N:18]([CH3:20])[CH:15]1[CH2:16][CH2:17][N:12]([CH2:11][C:9]2[S:10][C:5]3[C:4]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:3][C:2]([N:27]4[C:35]5[CH:34]=[CH:33][N:32]=[CH:31][C:30]=5[CH:29]=[CH:28]4)=[N:7][C:6]=3[CH:8]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 92205-AzaindoleHCID 575067401-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N,N-dimethylpiperidin-4-amine

Product 1

HCID 59606133HCID 59606133, compound

Procedure

Following General Procedure I for Buchwald coupling, 1-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N,N-dimethylpiperidin-4-amine and 1H-pyrrolo[3,2-c]pyridine were reacted to give 149. MS m/e 478.6 [M+H]+

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-33ec694465e641e6be7e2cdb3f2ded76
Source dataset
uspto-grants-2012_05
Patent number
US08173650B2

Reaction notes

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