HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 21949386, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 2-(4-Piperidyl)-2-propanol | HCID 5200321 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 21949386 | HCID 21949386 | — |
Reaction Steps
2-(Piperidin-4-yl)propan-2-ol (1 g) was reacted with 1.1 eq of benzyl chloroformate and 1.3 eq of triethylamine in 30 mL of chloroform. The reaction was halted after 2 days at room temperature and purified by isco (0-60% Hexanes/Ethyl Acetate over 20 minutes) to afford 1.49 g benzyl 4-(2-hydroxypropan-2-yl)piperidine-1-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173650B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-7b12655b845b4b1991a52d007f6193f7 |
| Source note | uspto-grants-2012_05 |