HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzimidazole → HCID 59606044, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzimidazole | HCID 5798 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | HCID 86624275 | HCID 86624275 | — |
| Product | HCID 59606044 | HCID 59606044 | — |
Reaction Steps
Following General Procedure J for Multi-Step Benzimidazole Formation by Buchwald coupling, 4-(2-chloro-6-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine and 1,2-diaminobenzene were reacted to give N1-(6-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)benzene-1,2-diamine which was cyclized with acetic acid to give 204. LCMS m/z: 497.6 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173650B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-05173af885464a3db3ffce85bebe6230 |
| Source note | uspto-grants-2012_05 |