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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1922983Generated: October 31, 2026

2-(Oxolan-2-yl)-1H-benzimidazole → HCID 59605243, compound

https://huagongshe.com/reaction/1922983

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Oxolan-2-yl)-1H-benzimidazoleHCID 3111393—
Reactant2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-olHCID 59603426—
ProductHCID 59605243HCID 59605243—

Reaction Steps

Following General Procedure I for Buchwald coupling, 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol and 2-(tetrahydrofuran-2-yl)-1H-benzimidazole were reacted to give 224. LCMS m/z: 561.3 (MH+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08173650B2
Source datasetuspto-grants-2012_05
ORD IDord-bf090143631b4174914171d6f74ca6eb
Source noteuspto-grants-2012_05