3-Fluoro-4-iodoquinoline → HCID 49832770, compound

HRID 1922984Notes

Reaction equation

HRID 1922984 reaction equation
[CH3:1][N:2]1[C:10]([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]([OH:21])([CH3:20])[CH3:19])[CH2:14][CH2:13]2)=[N:9][C:8]2[C:3]1=[N:4][C:5]([Sn](CCCC)(CCCC)CCCC)=[N:6][C:7]=2[N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.[F:41][C:42]1[CH:43]=[N:44][C:45]2[C:50]([C:51]=1I)=[CH:49][CH:48]=[CH:47][CH:46]=2>>[F:41][C:42]1[CH:43]=[N:44][C:45]2[C:50]([C:51]=1[C:5]1[N:4]=[C:3]3[C:8]([N:9]=[C:10]([CH2:11][N:12]4[CH2:13][CH2:14][CH:15]([C:18]([OH:21])([CH3:19])[CH3:20])[CH2:16][CH2:17]4)[N:2]3[CH3:1])=[C:7]([N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[N:6]=1)=[CH:49][CH:48]=[CH:47][CH:46]=2

Participants

3

Reactant 2

HCID 111084963-Fluoro-4-iodoquinolineHCID 596055362-(1-((9-Methyl-6-morpholino-2-(tributylstannyl)-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol

Product 1

HCID 49832770HCID 49832770, compound

Procedure

Following the procedure for 165, 2-[1-(9-methyl-6-morpholin-4-yl-2-(tributylstannanyl)-9H-purin-8-ylmethyl)piperidin-4-yl]propan-2-ol and 3-fluoro-4-iodoquinoline were reacted to give 225. LCMS m/z: 520.2 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4688a1cbbec749cbb55bf334cf4b6167
Source dataset
uspto-grants-2012_05
Patent number
US08173650B2

Reaction notes

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