2-Methylbenzimidazole → HCID 49832940, compound

HRID 1922989Notes

Reaction equation

Cl[C:2]1[N:3]=[C:4]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([C:18]([CH3:23])([CH3:22])[C:19]([NH2:21])=[O:20])[CH2:14][CH2:13]3)=[C:8]([CH3:24])[C:6]=2[N:7]=1.[CH3:31][C:32]1[NH:36][C:35]2[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=2[N:33]=1>>[CH3:22][C:18]([N:15]1[CH2:16][CH2:17][N:12]([CH2:11][C:9]2[S:10][C:5]3[C:4]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[N:3][C:2]([N:33]4[C:34]5[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=5[N:36]=[C:32]4[CH3:31])=[N:7][C:6]=3[C:8]=2[CH3:24])[CH2:13][CH2:14]1)([CH3:23])[C:19]([NH2:21])=[O:20]

Participants

Reactant 2

HCID 119842-Methylbenzimidazole

HCID 59603423HCID 59603423, compound

Product 1

HCID 49832940HCID 49832940, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide and 2-methyl-1H-benzo[d]imidazole were reacted to give 230. LCMS: M+H+=549.3

Workup

customwere reacted

Sources & evidence

ORD record: ord-c69ec1f792fa4231889c9d6080d7a85e
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173650B2

Reaction notes

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