2-Methylbenzimidazole → HCID 59606188, compound

HRID 1922995Notes

Reaction equation

Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:13][OH:14])[N:8]2[CH2:11][CH3:12])=[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:3]=1.[CH3:21][C:22]1[NH:23][C:24]2[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=2[N:26]=1>>[CH2:11]([N:8]1[C:7]([CH2:13][OH:14])=[N:6][C:5]2[C:9]1=[N:10][C:2]([N:23]1[C:24]3[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=3[N:26]=[C:22]1[CH3:21])=[N:3][C:4]=2[N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[CH3:12]

Participants

Reactant 2

HCID 119842-Methylbenzimidazole

HCID 58439142HCID 58439142, compound

Product 1

HCID 59606188HCID 59606188, compound

Procedure

(2-chloro-9-ethyl-6-morpholino-9H-purin-8-yl)methanol (2.3 g) was reacted with 2-methylbenzimidazole via General Procedure I for Buchwald coupling. The crude product (9-ethyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methanol (3g) was obtained after concentration of the reaction mixture and filtration after addition of water.

Sources & evidence

ORD record: ord-7fb25c733198443a86b0e4cdaac539e6
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173650B2

Reaction notes

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