(3-Methyloxetan-3-yl)methanamine → 1-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)-N-((3-methyloxetan-3-yl)methyl)methanamine

HRID 1923010Notes

Reaction equation

HRID 1923010 reaction equation
[CH3:1][N:2]1[C:10]([CH:11]=O)=[N:9][C:8]2[C:3]1=[N:4][C:5]([N:19]1[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[N:21]=[C:20]1[CH3:28])=[N:6][C:7]=2[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[CH3:29][C:30]1([CH2:34][NH2:35])[CH2:33][O:32][CH2:31]1>>[CH3:1][N:2]1[C:10]([CH2:11][NH:35][CH2:34][C:30]2([CH3:29])[CH2:33][O:32][CH2:31]2)=[N:9][C:8]2[C:3]1=[N:4][C:5]([N:19]1[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[N:21]=[C:20]1[CH3:28])=[N:6][C:7]=2[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 15789550(3-Methyloxetan-3-yl)methanamineHCID 596054202-(2-methylbenzoimidazol-1-yl)-9-methyl-6-morpholin-4-yl-9H-purine-8-carbaldehyde

Product 1

HCID 596060471-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)-N-((3-methyloxetan-3-yl)methyl)methanamine

Procedure

Following General Procedure L for reductive amination, 9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purine-8-carbaldehyde and (3-methyloxetan-3-yl)methanamine were reacted to give 259. [M+H]+ 463.6.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0d7762a8dc5a4c23ab45a9bec992b79f
Source dataset
uspto-grants-2012_05
Patent number
US08173650B2

Reaction notes

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