2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol → HCID 59605244, compound

HRID 1923065Notes

Reaction equation

HRID 1923065 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)=[CH:5][CH:4]=[N:3]1.Cl[C:17]1[N:25]=[C:24]2[C:20]([N:21]=[C:22]([CH2:27][N:28]3[CH2:33][CH2:32][CH:31]([C:34]([OH:37])([CH3:36])[CH3:35])[CH2:30][CH2:29]3)[N:23]2[CH3:26])=[C:19]([N:38]2[CH2:43][CH2:42][O:41][CH2:40][CH2:39]2)[N:18]=1>>[CH3:26][N:23]1[C:22]([CH2:27][N:28]2[CH2:33][CH2:32][CH:31]([C:34]([OH:37])([CH3:36])[CH3:35])[CH2:30][CH2:29]2)=[N:21][C:20]2[C:24]1=[N:25][C:17]([N:11]1[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=[C:7]1[C:6]1[N:2]([CH3:1])[N:3]=[CH:4][CH:5]=1)=[N:18][C:19]=2[N:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1

Participants

3

Reactant 2

HCID 596034262-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-olHCID 135646625HCID 135646625, compound

Product 1

HCID 59605244HCID 59605244, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-(1-methyl-1H-pyrazol-5-yl)-1H-benzo[d]imidazole and 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol were reacted to give 319. LCMS m/z: 571.3 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7b0daed13b3a48c6be42a55e84616e84
Source dataset
uspto-grants-2012_05
Patent number
US08173650B2

Reaction notes

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