HRID1923130

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78570

2-(Hydroxyethyl)benzimidazole

C9H10N2O

结构：Cn1c(CN2CCN(C(C)(C)CO)CC2)nc2c(N3CCOCC3)nc(Cl)nc21

HCID86648251

未命名化合物

PRODUCTS

生成物

结构：Cn1c(CN2CCN(C(C)(C)CO)CC2)nc2c(N3CCOCC3)nc(-n3c(CCO)nc4ccccc43)nc21

HCID59606156

未命名化合物

PROCEDURE

实验过程

Following General Procedure I for Buchwald coupling, 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropan-1-ol and 2-(1H-benzo[d]imidazol-2-yl)ethanol were reacted to give 427. LCMS m/z: 550.3 (MH+)

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d7fc415976ac482db5488b3616f009bb
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08173650B2
来源说明: uspto-grants-2012_05

反应 SMILES

Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH3:23])([CH3:22])[CH2:20][OH:21])[CH2:15][CH2:14]3)[N:8]2[CH3:11])=[C:4]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[N:3]=1.[NH:30]1[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[N:32]=[C:31]1[CH2:39][CH2:40][OH:41]>>[OH:41][CH2:40][CH2:39][C:31]1[N:30]([C:2]2[N:10]=[C:9]3[C:5]([N:6]=[C:7]([CH2:12][N:13]4[CH2:18][CH2:17][N:16]([C:19]([CH3:22])([CH3:23])[CH2:20][OH:21])[CH2:15][CH2:14]4)[N:8]3[CH3:11])=[C:4]([N:24]3[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)[N:3]=2)[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[N:32]=1