HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran-4-one → 4-(2-(2-Ethyl-1h-benzo[d]imidazol-1-yl)-9-methyl-8-((1-(tetrahydro-2h-pyran-4-yl)azetidin-3-yl)methyl)-9h-purin-6-yl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran-4-one | HCID 566735 | — |
| Reactant | 8-Azetidin-3-ylmethyl-2-(2-ethylbenzoimidazol-1-yl)-9-methyl-6-morpholin-4-yl-9H-purine | HCID 59605281 | — |
| Product | 4-(2-(2-Ethyl-1h-benzo[d]imidazol-1-yl)-9-methyl-8-((1-(tetrahydro-2h-pyran-4-yl)azetidin-3-yl)methyl)-9h-purin-6-yl)morpholine | HCID 49832942 | — |
Reaction Steps
Following General Procedure L, 2H-pyran-4(3H)-one underwent reductive amination with 4-(8-(azetidin-3-ylmethyl)-2-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-9H-purin-6-yl)morpholine to give 503. 517.3 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173650B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-3d9aa69785664856b7d7b22499c436de |
| Source note | uspto-grants-2012_05 |