Methyl vinyl sulfone → 4-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-((1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)methyl)-9H-purin-6-yl)morpholine

HRID 1923241Notes

Reaction equation

HRID 1923241 reaction equation
[CH3:1][N:2]1[C:10]([CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:9][C:8]2[C:3]1=[N:4][C:5]([N:24]1[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[N:26]=[C:25]1[CH3:33])=[N:6][C:7]=2[N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.[CH3:34][S:35]([CH:38]=[CH2:39])(=[O:37])=[O:36]>>[CH3:1][N:2]1[C:10]([CH2:11][CH:12]2[CH2:17][CH2:16][N:15]([CH2:39][CH2:38][S:35]([CH3:34])(=[O:37])=[O:36])[CH2:14][CH2:13]2)=[N:9][C:8]2[C:3]1=[N:4][C:5]([N:24]1[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[N:26]=[C:25]1[CH3:33])=[N:6][C:7]=2[N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 19354Methyl vinyl sulfoneHCID 596056364-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine

Product 1

HCID 596057894-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-((1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)methyl)-9H-purin-6-yl)morpholine

Procedure

Following General Procedure C, 4-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine and methylvinylsulfone were reacted to give 544. LCMS m/z: 553.3 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-20773f053e18423f82b624fc9b9fd266
Source dataset
uspto-grants-2012_05
Patent number
US08173650B2

Reaction notes

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