1-Tert-butylpiperazine → (4-tert-butylpiperazin-1-yl)(2-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methanone

HRID 1923262Notes

Reaction equation

HRID 1923262 reaction equation
[CH2:1]([C:3]1[N:7]([C:8]2[N:16]=[C:15]3[C:11]([N:12]=[C:13]([C:18](O)=[O:19])[N:14]3[CH3:17])=[C:10]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)[N:9]=2)[C:6]2[CH:27]=[CH:28][CH:29]=[CH:30][C:5]=2[N:4]=1)[CH3:2].[C:31]([N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)([CH3:34])([CH3:33])[CH3:32]>>[C:31]([N:35]1[CH2:40][CH2:39][N:38]([C:18]([C:13]2[N:14]([CH3:17])[C:15]3[C:11]([N:12]=2)=[C:10]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[N:9]=[C:8]([N:7]2[C:6]4[CH:27]=[CH:28][CH:29]=[CH:30][C:5]=4[N:4]=[C:3]2[CH2:1][CH3:2])[N:16]=3)=[O:19])[CH2:37][CH2:36]1)([CH3:34])([CH3:33])[CH3:32]

Participants

3

Reactant 2

HCID 35305721-Tert-butylpiperazineHCID 596053252-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purine-8-carboxylic acid

Product 1

HCID 59605490(4-tert-butylpiperazin-1-yl)(2-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methanone

Procedure

Following General Procedure K, 2-(2-Ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purine-8-carboxylic acid was coupled with 1-tert-butylpiperazine according to General Procedure K to give 567. LCMS m/z: 266.7 (2M+H+)

Sources & evidence

ORD record
ord-1b981e89b86240f6b2c805c1eb54a784
Source dataset
uspto-grants-2012_05
Patent number
US08173650B2

Reaction notes

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