HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Quinuclidin-4-ylcarbonyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-Azabicyclo(2.2.2)octane-4-carboxylic acid hydrochloride | HCID 66737825 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Quinuclidin-4-ylcarbonyl chloride hydrochloride | HCID 13760941 | — |
Reaction Steps
Quinuclidine-4-carboxylic acid hydrochloride (0.192 g, 0.001 mole) was suspended in dichloromethane (5 ml) and dimethylformamide (1 drop) and oxalyl chloride (0.436 ml. 0.635 g, 0.005 mole) were added. The resulting suspension was heated to reflux under an atmosphere of argon for six hours. Following concentration of the suspension in vacuo the residue was suspended in dichloromethane, concentrated in vacuo and finally dried in vacuo to give the title compound as a pale brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE043390E1 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f8c36db196cd4f3cbec6c561bc16468e |
| Source note | uspto-grants-2012_05 |