HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Quinuclidin-4-ylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Azabicyclo[2.2.2]octane-4-carbonitrile | HCID 141292 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Quinuclidin-4-ylmethanamine | HCID 22056669 | 94% |
Reaction Steps
4- Cyanoquinuclidine (0.31 g, 0.0028 moles) was reduced with lithium aluminium hydride (0.45 g, 0.012 moles) in tetrahydrofuran (20 ml) at ambient temperature for 18 hours. Diethyl ether (20 mls) was added followed by water (1.8 ml) and 10%w/v aqueous sodium hydroxide (0.68 ml) and the mixture stirred for 30 minutes. The mixture was then filtered and the filtrate concentrated in vacuo to give the title compound 0.3 g (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE043390E1 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-bbaeeaf588c64c02960459fd74f88c51 |
| Source note | uspto-grants-2012_05 |