HCID 67401067, compound → HCID 67401477, compound

HRID 1923405Notes

Reaction equation

HRID 1923405 reaction equation
[ClH:1].[N:2]12[CH2:9][CH2:8][C:5]([CH:10]=[CH:11][C:12]([OH:14])=[O:13])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2>[Pd]>[ClH:1].[N:2]12[CH2:9][CH2:8][C:5]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2

Participants

3

Reactant 1

HCID 67401067HCID 67401067, compound

Product 1

HCID 67401477HCID 67401477, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

3-(Quinuclidin-4-yl)-acrylic acid (Example 26, Step 4) (0.2 g, 0.0009 moles) was hydrogenated at atmospheric pressure and ambient temperature over 10% palladium on charcoal (0.05 g) for 18 hours. The catalyst was filtered off and the filtrate evaporated to dryness to give the title compound 0.18 g (89%); MS (+ve ion electrospray) m/z 184 (MH+, 100%).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-0fbdf86b0bec489b9ce5a3505c167e15
Source dataset
uspto-grants-2012_05
Patent number
USRE043390E1

Reaction notes

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