HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 1-Azabicyclo(2.2.2)octane-4-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 1-Azabicyclo(2.2.2)octane-4-carboxylic acid hydrochloride | HCID 66737825 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Azabicyclo(2.2.2)octane-4-methanol | HCID 141311 | 100% |
Reaction Steps
Quinuclidine-4-carboxylic acid hydrochloride (3.0 g, 0.016 moles) was treated with lithium aluminium hydride (2.5 g, 0.066 moles) in tetrahydrofuran (150 ml) at ambient temperature for 18 hours. The reaction was worked up as in the method of Example 25 Step 1 to give the title compound 2.24 g (100%). MS (+ve electrospray) m/z 142 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE043390E1 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-72925e67b0aa437591e33c93032d97d3 |
| Source note | uspto-grants-2012_05 |