tert-Butyl 4-oxopiperidine-1-carboxylate → Tert-butyl 4-hydroxypiperidine-1-carboxylate

Participants

Reaction Steps

1(tert-Butoxycarbonyl)-4-piperidone (5 g, 0.025 moles) was treated with sodium borohydride (1.89 g, 0.05 moles) as in the method of Example 37, Step 2 to give the title compound 5.07 g (100%); 1H NMR (CDCl3) inter alia 1.45 (9 H, s), 1.29-1.41 (2 H, m), 2.42-3.05 (2H, m), 3.75-3.99 (3H, m).

Provenance & Evidence