Ethanol → 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-, sodium salt, hydrate (1:1:5), (6R,7R)-

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Reaction Steps

To a reactor equipped with a jacket were added 10 ml ethanol, 50 ml dichloromethane, 20 ml water, 5 g cefazolin acid and 0.9 g sodium acetate, stirred until the solution was clear, the finishing point pH was adjusted to be 7.4, the mixture was directly filtered into a glass crystallizer, agitated for 60 minutes, added dropwise about 20 ml of isopropanol and methanol mixed liquid (the amount of methanol is 3%) and methionine, turbidness occurred in the solution, hold for 4.0 hours, added isopropanol and methanol in a volume 10 times as much as the mixture at 1.5 MPa. The resultant was filtered, the filter cake was washed with acetic acid, dried at 80° C. for 0.5 hours to give cefazolin sodium pentahydrate.

Provenance & Evidence