HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 4-Bromo-2-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-2-fluorobenzoyl chloride | HCID 2734026 | — |
Reaction Steps
4-Bromo-2-fluorobenzoic acid (1.0 mmol) and oxalyl chloride (2.0 mmol) are combined in dichloromethane (0.10 M), and 2 drops of dimethylformamide are added as a catalyst. The reaction is stirred at room temperature for 3 h. After this time, the reaction is concentrated in vacuo. Total conversion to the acid chloride is assumed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178528B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-165c3d670e71451e9b71b391342db6f5 |
| Source note | uspto-grants-2012_05 |