4-Bromo-2-fluorobenzoic acid → HCID 57980158, compound

HRID 1923473Notes

Reaction equation

HRID 1923473 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH3:12][C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[CH2:18][C@@H:19]1[CH2:23][CH2:22][CH2:21][NH:20]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:20]2[CH2:21][CH2:22][CH2:23][C@H:19]2[CH2:18][N:14]2[CH2:15][CH2:16][CH2:17][C@H:13]2[CH3:12])=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

3

Reactant 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 57980158HCID 57980158, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure C (see example 32) from 4-bromo-2-fluoro-benzoic acid (CAS 112704-79-7) and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (FIA) 369/371 (MH+).

Sources & evidence

ORD record
ord-2b09c1d46dde4608bd23de650cb279b2
Source dataset
uspto-grants-2012_05
Patent number
US08178528B2

Reaction notes

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