Dimethyl-1,3-thiazole-5-carboxylic acid → HCID 66643786, compound

Participants

Reaction Steps

To a stirred solution of 2,4-dimethyl-thiazole-5-carboxylic acid (250 mg, 1.59 mmol) in THF (16 mL) at −78° C. and under argon was added LDA (1.6 mL of a 2M solution in THF, 3.2 mmol) dropwise. After 1.5 h a solution of 4-chloromethyl-5-methyl-3-phenyl-isoxazole (330 mg, 1.59 mmol) in THF (4 mL) was added dropwise. After 1 h the reaction mixture was quenched with HCl (1N, 10 mL) then warmed to room temperature and extracted with ethyl acetate. The combined extracts were dried, filtered and concentrated. Purification by chromatography (silica, 0 to 10% methanol in dichloromethane) gave the title compound (315 mg, 60%) as a light yellow gum. MS: m/e=329.1 [M+H]+.

Provenance & Evidence