Ethanamine, 2,2,2-trifluoro- → HCID 49782924, compound

HRID 1923509Notes

Reaction equation

HRID 1923509 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([CH2:10][CH2:11][C:12]2[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)=[N:14][O:15][CH:16]=2)[S:5][C:6]=1[C:7]([OH:9])=O.[F:23][C:24]([F:28])([F:27])[CH2:25][NH2:26]>>[F:23][C:24]([F:28])([F:27])[CH2:25][NH:26][C:7]([C:6]1[S:5][C:4]([CH2:10][CH2:11][C:12]2[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)=[N:14][O:15][CH:16]=2)=[N:3][C:2]=1[CH3:1])=[O:9]

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 666437194-Methyl-2-[2-(3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid

Product 1

HCID 49782924HCID 49782924, compoundYield 93%

Procedure

As described for example 19, 4-methyl-2-[2-(3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (70 mg, 0.22 mmol) was converted, using 2,2,2-trifluoroethylamine instead of 4-aminotetrahydropyran, to the title compound (82 mg, 93%) which was obtained as an off white solid MS: m/e=397.1 [M+H]+.

Sources & evidence

ORD record
ord-8ee921990f6448efa241d4a554a28475
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

Loading…