Lithium hydroxide, monohydrate → HCID 66643592, compound

Participants

Reaction Steps

To a suspension of 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid methyl ester (835 mg, 2.54 mmol) in THF (8 mL) was added a solution of lithium hydroxide monohydrate (165 mg, 3.9 mmol) in water (8 mL) and the resulting mixture stirred at room temperature for 45 min. The mixture was then evaporated to half volume and then acidified to pH 1 with HCl (1N) and cooled to 0° C. for 15 min. A solid precipitated and was filtered off and dried to afford the title compound (769 mg, 96%) which was obtained as an off white solid. MS: m/e=314.1 [M−H]−.

Provenance & Evidence