Isopropylamine → HCID 49782488, compound

Participants

Reaction Steps

To a solution of 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (77 mg, 0.24 mmol) in DMF (3 mL) were added 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (86 mg, 0.27 mmol), N,N-diisopropyl ethyl amine (208 μL, 1.21 mmol) and isopropylamine (16 mg, 0.27 mmol). The resulting reaction mixture was stirred for 2 h and then evaporated. Purification by chromatography (silica, heptane:ethyl acetate 1:1 to 0:1) afforded the title compound (81 mg, 93%) as an off white solid. MS: m/e=357.2 [M+H]+.

Provenance & Evidence