Cyclopropylamine → HCID 49782489, compound

HRID 1923512Notes

Reaction equation

[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][CH2:14][C:15]1[S:16][C:17]([C:20]([OH:22])=O)=[CH:18][N:19]=1.[CH:23]1([NH2:26])[CH2:25][CH2:24]1>>[CH:23]1([NH:26][C:20]([C:17]2[S:16][C:15]([CH2:14][CH2:13][C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:19][CH:18]=2)=[O:22])[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 66643592HCID 66643592, compound

Product 1

HCID 49782489HCID 49782489, compoundYield 80%

Procedure

As described for example 22b, 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (73 mg, 0.23 mmol) was converted, using cyclopropylamine instead of isopropylamine, to the title compound (66 mg, 80%) which was obtained as an off white solid MS: m/e=355.2 [M+H]+.

Sources & evidence

ORD record: ord-92222449860241d48c077ba84612864c
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178522B2

Reaction notes

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