Ethanolamine → HCID 59568502, compound

HRID 1923517Notes

Reaction equation

[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][CH2:14][C:15]1[S:16][C:17]([C:20]([OH:22])=O)=[CH:18][N:19]=1.[CH2:23]([CH2:25][NH2:26])[OH:24]>>[OH:24][CH2:23][CH2:25][NH:26][C:20]([C:17]1[S:16][C:15]([CH2:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[N:19][CH:18]=1)=[O:22]

Participants

Reactant 2

HCID 700Ethanolamine

HCID 66643592HCID 66643592, compound

Product 1

HCID 59568502HCID 59568502, compoundYield 35%

Procedure

As described for example 22b, 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (73 mg, 0.23 mmol) was converted, using ethanolamine instead of isopropylamine, to the title compound (29 mg, 35%) which was obtained as a white solid MS: m/e=359.1 [M+H]+.

Sources & evidence

ORD record: ord-a3b0228d75594850b19a7f24d8f0f53d
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178522B2

Reaction notes

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