Ethanolamine → HCID 49782709, compound

HRID 1923537Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([CH2:13][CH2:14][C:15]3[S:16][C:17]([C:20]([OH:22])=O)=[CH:18][N:19]=3)=[C:11]([CH3:23])[O:10][N:9]=2)=[N:6][CH:7]=1.[CH2:24]([CH2:26][NH2:27])[OH:25]>>[OH:25][CH2:24][CH2:26][NH:27][C:20]([C:17]1[S:16][C:15]([CH2:14][CH2:13][C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][N:6]=3)=[N:9][O:10][C:11]=2[CH3:23])=[N:19][CH:18]=1)=[O:22]

Participants

Reactant 2

HCID 700Ethanolamine

HCID 66643727HCID 66643727, compound

Product 1

HCID 49782709HCID 49782709, compoundYield 41%

Procedure

As described for example 40c, 2-{2-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-ethyl}-thiazole-5-carboxylic acid (67 mg, 0.20 mmol) was converted, using ethanolamine instead of 4-aminotetrahydropyran, to the title compound (65 mg, 41%) which was obtained as a white solid. MS: m/e=377.2 [M+H]+.

Sources & evidence

ORD record: ord-25715cd952fc4db9b9a91f8e7b7f023a
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178522B2

Reaction notes

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