Thionyl Chloride → HCID 66643618, compound

HRID 1923541Notes

Reaction equation

HRID 1923541 reaction equation
[CH2:1]([C:5]1[C:9]([CH2:10]O)=[C:8]([CH3:12])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4].S(Cl)([Cl:15])=O>C(Cl)Cl>[CH2:1]([C:5]1[C:9]([CH2:10][Cl:15])=[C:8]([CH3:12])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 66599297(3-Butyl-5-methyl-isoxazol-4-yl)-methanol

Product 1

HCID 66643618HCID 66643618, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (3-butyl-5-methyl-isoxazol-4-yl)-methanol (1.0 g, 6 mmol) in DCM (10 mL) at 0° C. was added thionyl chloride (1.46 g, 12 mmol) and the resulting mixture stirred for 1 h and then evaporated. After 1 h the reaction mixture was concentrated to give the title compound (1.04 g, 94%) as a light brown liquid. MS: m/e=188.2 [M+H]+.

Workup

  1. customevaporated
  2. concentrationAfter 1 h the reaction mixture was concentrated

Sources & evidence

ORD record
ord-a16fa92aca0d48a8bd7f3f708e104656
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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