反应详情

To a solution of (3-butyl-5-methyl-isoxazol-4-yl)-methanol (1.0 g, 6 mmol) in DCM (10 mL) at 0° C. was added thionyl chloride (1.46 g, 12 mmol) and the resulting mixture stirred for 1 h and then evaporated. After 1 h the reaction mixture was concentrated to give the title compound (1.04 g, 94%) as a light brown liquid. MS: m/e=188.2 [M+H]+.

1. customevaporated
2. concentrationAfter 1 h the reaction mixture was concentrated