Serinol → HCID 49782042, compound

Participants

Reaction Steps

To a stirred solution of 2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid methyl ester (100 mg, 0.31 mmol) in toluene (1.0 mL) was added 2-amino-1,3-propandiol (57 mg, 0.62 mmol) and TBD (13 mg, 0.09 mmol). After 15 h the reaction mixture was concentrated in vacuo then purified by chromatography (silica, 0 to 7.5% methanol in dichloromethane) to give the title compound (65 mg, 55%) as an off white oil.

Provenance & Evidence