(R)-(-)-2-Amino-1-propanol → HCID 49782272, compound

HRID 1923551Notes

Reaction equation

HRID 1923551 reaction equation
CO[C:3]([C:5]1[S:9][C:8]([CH2:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])=[N:7][C:6]=1[CH3:22])=[O:4].[NH2:23][C@@H:24]([CH2:26][OH:27])[CH3:25]>>[OH:27][CH2:26][C@H:24]([NH:23][C:3]([C:5]1[S:9][C:8]([CH2:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])=[N:7][C:6]=1[CH3:22])=[O:4])[CH3:25]

Participants

3

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 666436812-[2-(3-Butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid methyl ester

Product 1

HCID 49782272HCID 49782272, compoundYield 75%

Procedure

As described for example 53, 2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid methyl ester (100 mg, 0.31 mmol) was converted, using D-alaninol instead of 2-amino-1,3-propandiol, to the title compound (85 mg, 75%) which was obtained as an off white oil. MS: m/e=366.0 [M+H]+.

Sources & evidence

ORD record
ord-73fa306bca214d69bda0c67ce21a1e1b
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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