反应详情

To a stirred solution of 2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid methyl ester (170 mg, 0.55 mmol) in toluene (0.5 mL) was added rac-2-amino-1-propanol (83 mg, 1.1 mmol) and TBD (23 mg, 0.017 mmol). After 15 h the reaction mixture was concentrated in vacuo then purified by chromatography (silica, 0 to 7% methanol in dichloromethane) to give the title compound (85 mg, 44%) as a pale yellow oil.

1. concentrationAfter 15 h the reaction mixture was concentrated in vacuo
2. customthen purified by chromatography (silica, 0 to 7% methanol in dichloromethane)